Generate Innovative Celltherapy by Controlling the Immune System.


About Us

Corporate Message

Corporate message
Shimon Sakaguchi (CTO)

We founded Regcell Co., Ltd. in January, 2016. RegCell aims to generate novel therapeutic technologies through augmenting or controlling the immune system and our goal is to save patients who suffer from autoimmune diseases and cancer .

I have been continuing the research about immunology in particular studying the character and the function of Regulatory T cells (Tregs) for more than 30 years and I have been able to understand it’s roles with regard to the symptom or mechanism of autoimmune diseases, allergy and immune-reactions related to organ transplantation. Currently, many researchers are focusing on the development and function of Tregs for the purpose of applying it to actual clinical use.

Treg is a lymphocyte specialized in suppressing immune function, and it will be possible to cure autoimmune disease like rheumatoid arthritis, relieve allergic symptoms, and inhibit immune reactions related to the organ transplantation through expansion or functional enhancement of antigen-specific Treg. On the other hand, it will also be possible to enhance the immune response to cancer and the pathogenic microbe through the decrease or functional suppression of Treg. Clinical trials of Treg have been conducted abroad for practical medical use of Treg.
Regcell aims to generate novel medical technologies using Tregs and provide innovative medical solutions for patients as commercially available therapy.

Furthermore, Regcell aims to develop new cancer immunotherapy using cytotoxic T lymphocyte (CTL) attacking cancer. We are developing a new concept that is highly effective cancer immunotherapy using CTL derived from iPSC. Dr. Hiroshi Kawamoto, professor of Institute for Frontier Life and Medical Sciences, Kyoto University leads this project.

Regcell will contribute to improving the health of people worldwide in terms of both immune-suppression and immune-enhancement.



Shimon Sakaguchi
Institutions Attended: Kyoto University Medical School Doctor of Medicine (1970-1976)
Kyoto University Medical School Doctor of Philosophy (Ph.D.) (1983 )
Professor: Institute for Frontier Medical Sciences, Kyoto University (1998-2011)
Director: Institute for Frontier Medical Sciences, Kyoto University (2007-2011)
Professor: Immunology Frontier Research Center, Osaka University (2011- present)
Vice-director, Immunology Frontier Research Center, Osaka University (2012 -present)
Distinguished Professor, Osaka University (2013- present)
Chief Technical Officer: RegCell Co., Ltd. (2016- present)Awards
Japan Academy Award (2012)
Canada Gairdner International Award (2015)
Thomson Reuters Citation Laureates (2015)
Person of Cultural Merits (2017)
Order of Culture (2019)


Director, President & CEO
Yasuhiko Handa
Manager of Procurement, AED(Aircraft Equipment Division), Shimadzu Corporation (2006-2008)
Senior Manager, Japan branch office, Shimadzu Precision Instruments, Inc. (2008-2014)
Manager of Business Planning Department, AED, Shimadzu Corporation (2014-2017)
Executive Officer, iPS PORTAL, Inc. (2017-2019)
Director, President & CEO, Regcell Co., Ltd. (2019-)


Director, Executive Vice President
Noriko Sakaguchi
Institutions Attended: Nagoya City University Medical School, Doctor of Medicine (1974-1980)
Resident: Nagoya City University, Kyoto University, Ootsu Red Cross Hospital (1980-1983)
Postdoctoral Fellow: The Johns Hopkins University, Stanford University, Scripps Institute (1983-1989)
Research Associate,: Tokyo Metropolitan Institute of Gerontology, Institute for Frontier Medical Sciences, Kyoto University (1998-2008)
Specially appointed Assistant Professor (full time):Immunology Frontier Research Center, Osaka University (2008-2016)
Executive Director, Vice President, Research Division: RegCell Co., Ltd. (2016-2018)
President and CEO, Regcell Co., Ltd. (2018-)


Director, Member of the Board
Shuh Narumiya
M.D. (1973, Kyoto University),
Ph.D. (1979, Kyoto University Graduate School of Medicine)
Professor in Pharmacology (1992-2013) and Dean (2004-2007), Kyoto University Graduate School of Medicine
Presently Project Professor and Director, Medical Innovation Center, Kyoto University Graduate School of MedicineAwards
The Japan Academy Award
Lorenzini Gold Medal
and Ulysses Medal
Person of Cultural Merit 2017

Audit & Supervisory Board Member
Amemiya Sayaka
Bachelor of Laws, Kyoto University, Kyoto(2003)
57th Legal apprentices(2003)
Osaka Bar Association(2004-present)
Lawyer: Yodoyabashi & Yamagami Legal Professional Corparation(2004-present)
Audit & Supervisory Board Member: RegCell Co., Ltd. (2017-present)

Adviser consultant

Kayo Inaba
Executive Vice President
Kyoto University

Kazuhiko Yamamoto
Center for Integrative Medical Sciences

Minoru Kubota

Zenichi Mori

Keiko Iwaisako
Doshisha University
Faculty of Life and Medical Sciences
Department of Medical Life Systems

Atsushi Tanaka
Assistant Professor
Osaka University
Immunology Frontier Research Center


Company Name RegCell Co., Ltd
Established in 27-Jan-16
Address Osaka University, Research Institite for Microbial Diseases, North Building 1F, 3-1 Yamadaoka, Suita-City, Osaka 565-0871 Japan
Number of employees 5 (as of the end ofMarch 2020)


By Train : Approximately 7 minutes’ walk from Keihan-Line, “Demachi Yanagi” Station.
By Bus : Approximately 25 minutes from JR Kyoto Station to “Kawaramachi Imadegawa”, and approximately 2 minutes’ walk from the bus stop.
By Taxi : Approximately 15 minutes from JR Kyoto Station.


Induction and amplification culture of Treg

In the immune system of the humans, basically, the immune cells attacking “the self” are removed in the process of the development in thymus. However, some immune cells happen to survive and may attack “the self” recklessly. Although Treg acts as a brake (suppressor), the imbalance between the accelerator and the brake may result in the development of an autoimmune disease. In this case, it would be possible to cure autoimmune disease by increasing Treg or decreasing CTL in patients.Regcell has built the technologies, as mentioned below, which enable such medical cure.

-Technology to separate and expand nTreg (natural Treg) from a patient’s blood and return it to the same patients.
-Technology to induce iTreg (induced Treg) from all kinds of T cell and exclude Treg after expanding all types of T cell by cultivation.
-Technology to induce antigen-specific nTreg/iTreg that suppresses immunoreaction specific for certain antigen.

It is thought to be possible to cure allergic disease or GVHD on transplantation and not only autoimmune disease by using these technologies.



In the immune suppression field, we are planning a clinical trial of autologous-Treg therapy for a refractory autoimmune disease as a first indication by using Treg manufactured by the induce/expansion technology of Regcell. At this moment, we are working on the evaluation using a disease model-animal and the establishment of cell processing method for clinical use, and plan to start the first-in-human trial in 2020.


Anti GITR antibody (mouse; DTA-1 clone) hybridoma

GITR (glucocorticoid-induced TNF receptor family) is highly expressed on Treg. The DTA-1 antibody binds to this molecule specifically and weakens the function of Treg by putting the agonistic stimulation in Treg. Regcell is providing the hybridoma that produces this antibody. Please contact us for further details on the provision of hybridoma.

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